In the absence of a submission from the holder of the marketing authorisation, phentolamine mesylate (OraVerse®) cannot be endorsed for use within NHS Wales for reversal of soft tissue anaesthesia (lip and tongue), and the associated functional deficits, resulting from an intraoral submucosal injection of a local anaesthetic containing a catecholamine vasoconstrictor, such as epinephrine, following a routine dental procedure such as teeth cleaning, scaling and planing, cavity filling or crowns.