Colesevelam (Cholestagel®) has not been endorsed for use within NHS Wales in combination with ezetimibe, with or without a statin, for the treatment of adult patients with primary hypercholesterolaemia, including patients with familial hypercholesterolaemia. The holder of the marketing authorisation is not in a position to progress a submission to AWMSG for the appraisal of colesevelam (Cholestagel®) for the above indication. As a result, AWMSG cannot provide advice to the Minister for Health and Social Services.