Skip to main content

What's on the 'Spice' rack? Synthetic cannabinoid receptor agonist toxicity reported to the UK National Poisons Information Service



Author/s Hill S, Cooper G, Jackson G, Lupton D, Bradberry S, Thomas S
Year 2013
Type of publication Conference proceeding
Link https://doi.org/10.3109/15563650.2013.785188
Abstract

Objective: To describe the features of synthetic cannabinoid receptor agonist (SCRA) toxicity as reported to the UK National Poisons Information Service (NPIS)

Methods: User sessions related to SCRA on TOXBASE®, the NPIS on-line information resource were quantified from 1st January 2010 to 30th June 2012. NPIS telephone enquiries from healthcare professionals were reviewed from 1st January 2011 to 30th June 2012.

Results: Monthly TOXBASE accesses for SCRA increased over the study period. Of a total of 532 TOXBASE sessions 334 (63%) were for ‘Black Mamba’, a product containing the newer SCRA AM-22011. There were 53 telephone enquiries to NPIS related to SCRA, (39 males, 13 females, 1 not recorded), median age 20 (range 13–52). Fifty-one calls related to ‘products,’ including ‘Black-Mamba’ (n = 28), ‘Herbal-Haze’ (n = 9). Of these 43 were from hospitals, 4 from ambulance services and 6 from primary care. Smoking was the route of exposure in 41 cases (77%). Median time from exposure to NPIS enquiry was 3 hours, suggesting early symptom onset. Nine enquiries involved the use of other substances. There was one death, in a patient who had reportedly jumped from a balcony following use of a SCRA product called ‘heavy haze incense’.

Conclusion: NPIS data can be used to describe patterns of presentation and reported clinical toxicity for emerging psychoactive including new products (e.g. black mamba) and chemicals.

Reference:

  1. McQuade D, Hudson S, Dargan PI, et al. First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201. Eur J Clin Pharmacol 2013; 69:373–6.

Follow AWTTC: