| Author/s | Coulson J |
| Year | 2014 |
| Type of publication | Journal article |
| Link | https://www.jpgmonline.com/text.asp?2014/60/1/31/128804 |
| Abstract | Poisoning with organophosphorus pesticides is a significant global health problem and is the principle cause of death through self-poisoning in India. The organophosphates potentiate the action of acetylcholine through the inhibition of synaptic acetylcholinesterase. Standard treatment includes resuscitation and the administration of atropine and an oxime, such as pralidoxime. There is a lack of high quality evidence to support the efficacy of either antidote. Atropine is considered to be effective at antagonizing the features of excessive muscarinic stimulation. The efficacy of pralidoxime is more contentious. |