| Author/s | Coulson J, Thompson J |
| Year | 2013 |
| Type of publication | Journal letter |
| Link | https://doi.org/10.3109/15563650.2013.820313 |
| Abstract | We were greatly interested in the results of a recent observational case series in which Schmidt described an inverse correlation between the admission paracetamol (acetaminophen) plasma concentration and the development of systemic anaphylactoid features, following treatment with a standard regime of intravenous N-acetylcystine (NAC).1 This observation, as the author acknowledges, has previously been described2 but lacks a comprehensive mechanistic explanation. We have observed that paracetamol is capable of modifying NAC-induced histamine secretion from both human peripheral blood mononucleocytes (PBMCs) and the non-IgE-expressing human mast cell line 1 (HMC-1) in vitro.3 We suggest that our results both support Schmidt's finding and provide a degree of mechanistic insight. |