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NICE TAs

05/03/2020
TA367: Vortioxetine for treating major depressive episodes

Published date: We reviewed the evidence in November 2018. We found nothing new that affects the recommendations in this guidance.

05/03/2020
TA272: Vinflunine for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract

Published date: We reviewed the evidence in January 2016. We found nothing new that affects the recommendations in this guidance.

05/03/2020
TA179: Sunitinib for the treatment of gastrointestinal stromal tumours

Published date: We reviewed the evidence in July 2017. We found nothing new that affects the recommendations in this guidance.

05/03/2020
TA335: Rivaroxaban for preventing adverse outcomes after acute management of acute coronary syndrome

Published date: We reviewed the evidence in March 2018. We found nothing new that affects the recommendations in this guidance.

05/03/2020
TA482: Immunosuppressive therapy for kidney transplant in children and young people

Published date: Next review: 2020

05/03/2020
TA306: Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin's B‑cell lymphoma

Published date: In July 2017, we decided that we will review the evidence within 6 months of publication of the PIX306 trial results.

05/03/2020
TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer

Published date: Next review: 2019

05/03/2020
TA610: Pentosan polysulfate sodium for treating bladder pain syndrome

Published date: Next review: 2022

There is a simple discount patient access scheme for pentosan polysulfate sodium

05/03/2020
TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin

Published date: Next review: 2019 This guidance replaces TA309.

05/03/2020
TA339: Omalizumab for previously treated chronic spontaneous urticaria

Published date: 

We reviewed the evidence in July 2018. We found nothing new that affects the recommendations in this guidance.

05/03/2020
TA494: Naltrexone–bupropion for managing overweight and obesity

Published date: We reviewed the evidence in January 2020. We found nothing new that affects the recommendations in this guidance.

05/03/2020
TA318: Lubiprostone for treating chronic idiopathic constipation

This guidance has been withdrawn because Takeda has discontinued lubiprostone (Amitiza).

05/03/2020
TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma

Published date: Next review: 2021

05/03/2020
TA527: Beta interferons and glatiramer acetate for treating multiple sclerosis

Published date: Next review: 2021

05/03/2020
TA359: Idelalisib for treating chronic lymphocytic leukaemia

Published date: We reviewed the evidence in September 2018. We found nothing new that affects the recommendations in this guidance.

September 2016: The European Medicines Agency has reviewed idelalisib and the marketing authorisation has been updated.

For people taking idelalisib as a first therapy, the marketing authorisation now states that idelalisib is for ‘first-line treatment in the presence of 17p deletion or TP53 mutation in patients who are not eligible for any other therapies’.

Additional information about infections has been included in the marketing authorisation.

05/03/2020
TA491: Ibrutinib for treating Waldenstrom's macroglobulinaemia

Published date: Next review: More evidence on ibrutinib is being collected, until September 2020. After this NICE will decide whether or not to recommend it for use on the NHS and update the guidance. It will be available through the Cancer Drugs Fund until then.

05/03/2020
TA429: Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation

Published date: Next review: 2020

05/03/2020
TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma

Published date: Next review: 2021

05/03/2020
TA481: Immunosuppressive therapy for kidney transplant in adults

Evidence-based recommendations on immunosuppressive therapies for preventing kidney rejection in adults. The therapies are basiliximab (Simulect), immediate-release tacrolimus (Adoport, Capexion, Modigraf, Prograf, Tacni, Vivadex), mycophenolate mofetil (Cellcept and non-branded versions), rabbit anti-human thymocyte immunoglobulin (Thymoglobuline), prolonged-release tacrolimus (Advagraf, Envarsus), mycophenolate sodium (Myfortic, Ceptava), sirolimus (Rapamune), everolimus (Certican) and belatacept (Nulojix).

Published date: Next review: 2020

05/03/2020
TA348: Everolimus for preventing organ rejection in liver transplantation

Published date: We reviewed the evidence in July 2018. We found nothing new that affects the recommendations in this guidance.

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