Skip to main content

COVID-19: Update log

[05/05/2022 - 16.16]

COVID-19 therapies - Alerts and advice: 'Barictinib' section updated with latest Interim Clinical Commissioning Policy, Public Health Link and Clinical Guide.

[01/03/2022 - 09.55]

COVID-19 therapies - Alerts and advice: 'Neutralising monoclonal antibodies or antivirals' section for non-hospitalised patients updated with latest Interim Clinical Commissioning Policy and accompanying Public Health Link.

[24/02/2022 - 16:00]

COVID-19 therapies - Alerts and advice: 'Remdesivir' section updated with latest Interim Clinical Commissioning Policy and accompanying Pharmaceutical Public Link. 'Neutralising monoclonal antibodies or antivirals' section for hospitalised patients updated with latest Interim Clinical Commissioning Policies, associated clinical guides and accompanying Public Health Alerts. 

[01/02/2022 - 14:58]

COVID-19 therapies - Alerts and advice: 'Interleukin-6 inhibitors (tocilizumab or sarilumab) section updated with latest Interim Clinical Commissioning Policy and accompanying Pharmaceutical Public link.

[31/01/2022 - 16:38]

COVID-19 therapies - Alerts and advice: 'Palivizumab' section updated with latest Rapid Policy Statement and Public Health Alert.

[31/01/2022 - 11:00]

COVID-19 therapies - Alerts and advice: 'Neutralising monoclonal antibodies or antivirals' section updated with latest Interim Clinical Commissioning Policies, associated clinical guides and accompanying Public Health Alerts.

[04/01/2022 - 16:13]

COVID-19 therapies - Alerts and advice: 'Neutralising monoclonal antibodies or antivirals' section updated with latest Interim Clinical Commissioning Policies and accompanying Public Health Alerts.

[17/12/2021 - 13:42]

COVID-19 therapies - Alerts and advice: 'Casirivimab/imdevimab' section has been incorporated into 'Neutralising monoclonal antibodies or antivirals' section, and more recently published (16 December) Interim Clinical Commissioning Policies and accompanying Public Health Alerts have been added.

[16/12/2021 - 10:24]

COVID-19 therapies - Alerts and advice: Added links to National COVID-19 treatment Patient Group Directions (PGDs) templates, developed by the Welsh Medicines Information Centre, to 'Casirivimab/imdevimab' and 'Neutralising monoclonal antibodies or antivirals' sections.

[14/12/2021 - 17:21]

COVID-19 therapies - Alerts and advice: Updated section for 'Corticosteroids' with new Pharmaceutical Public Link notification and Therapeutic alert on the withdrawal of recommendations for the consideration of inhaled budesonide as a treatment option for COVID-19.

[9/12/2021 - 09:57]

New Interim Clinical Commissioning Policy for 'Neutralising monoclonal antibodies or antivirals added to the 'COVID-19 Therapies - alerts and advice' page.

[30/11/2021 - 14:43]

Added Public Health Link summary of COVID-19 B.1.1.529 variant to the 'Wales' section of the 'COVID-19 Vaccines' page.

[26/11/2021 - 15:49]

Added 'National protocol for Comirnaty COVID-19 mRNA vaccine' to the 'COVID-19 vaccines' page (within the 'Wales' sub-section).

[24/11/2021 - 10:02]

'Ivermectin' section of the 'Specific areas of interest' page has been removed.

[10/11/2021 - 09:11]

Updated letter from the CMO and CPO for Wales for casirivimab/imdevimab added to the 'COVID-19 Therapies - alerts and advice' page.

[04/11/2021 - 17:14]

Updated entry for Interim Clinical Commissioning Policy: casirivimab and imdevimab for patients hospitalised due to COVID-19 on the 'COVID-19 Therapies - alerts and advice' page to link to latest version published on 04/11/21.

[12/10/2021 - 15:20]

Added link to October 2021 MHRA summary of vaccine updates to the 'General' section of the 'COVID-19 Vaccines' page.

[28/09/2021 - 16:22]

Added link to September 2021 MHRA summary of vaccine updates to the 'General' section of the 'COVID-19 Vaccines' page.

[21/09/2021 - 17:45]

Additional link to SPS resources added to casirivimab/imdevimab entry on the 'COVID-19 Therapies - alerts and advice' page.

[21/09/2021 - 09:54]

New letter from the CMO and CPO for Wales and an Interim Clinical Commissioning Policy for casirivimab/imdevimab added to the 'COVID-19 Therapies - alerts and advice' page.

[14/09/2021 - 17:39]

New letter from the CPO for Wales and Interim Clinical Commissioning Policies for Sarilumab and Tocilizumab (IL-6 inhibitors) added to the 'COVID-19 Therapies - alerts and advice' page.

[10/09/2021 - 14:41]

Added link to additional WMIC advice alongside CMO letter and Q&A document for 'Third vaccine doses in severly immunocompromised patients' ('Wales' section of the 'COVID-19 Vaccines' page).

[03/09/2021 - 10:02]

Added letter from the CMO and Q&A document for 'Third vaccine doses in severly immunocompromised patients' to the 'Wales' section of the 'COVID-19 Vaccines' page.

[20/08/2021 - 15:24]

Added entry for 'Ronapreve' to 'COVID-19 Therapies - alerts and advice' page.

[18/08/2021 - 16:47]

Added link to August 2021 MHRA summary of vaccine updates to the 'General' section of the 'COVID-19 Vaccines' page.

[17/08/2021 - 16:26]

Link to SPS page on 'Interactions information for COVID-19 vaccines' added to the 'General' section of the 'COVID-19 Vaccines' page.

[12/08/2021 - 10:27]

Link to National Patient Safety Alert added to 'Antiocoagulants' section of the 'Specific areas of interest' page.

[10/08/2021 - 15:16]

Updated the One Wales prostate cancer decision on the 'Specific areas of interest' page.

[10/08/2021 - 13:43]

Added link to Welsh Government 'Care homes and social services: coronavirus' page to the 'Care home prescribing' page.

[03/08/2021 - 15:55]

Added links to Welsh Government 'Vaccines: Coronavirus' page and 'Directions and immunisation scheme specification' for Pfizer/BioNTech vaccine added to the 'Wales' section of the 'COVID-19 vaccines' page.

[21/07/2021 - 12:26]

Added links to 'COVID-19 Vaccine Allergy Service' and 'JCVI advice on COVID-19 vaccination of children and young people' to the 'COVID-19 vaccines' page ('Wales' and 'General' sections, respectively). 

[13/07/2021 - 16:43]

Added a new section for 'Ivermectin' to 'Specific areas of interest' page.

[09/07/2021 - 15:24]

Added link to a July 2021 MHRA Drug Safety Update in the 'Management of oral retinoid medicines during the COVID-19 pandemic' section of 'Specific ares of interest' page.

[02/07/2021 - 10:49]

Statement added to 'End of Life Medicines Service' page, stating that the service is currently suspended.

[01/07/2021 - 14:36]

Added letter from the CMO and Rapid Policy Statement for 'Palivizumab' added to 'COVID-19 Therapies - alerts and advice' page.

[29/06/2021 - 11:04]

Added link to the letter from the CMO and CPO on the revisions to the product information for COVID-19 Vaccine Moderna and Pfizer/BioNTech COVID-19 vaccine.

[15/06/2021 - 12:52]

Updated published information for 'Remdesivir' on the 'COVID-19 Therapies - alerts and advice' page.

[07/06/2021 - 17:15]

Added link in the 'General' area of the 'COVID-19 Vaccines' section for MHRA concluding a positive safety profile for Pfizer/BioNTech vaccine in 12- to 15-year-olds.

[28/05/2021 - 14:01]

Added link to UK Chemotherapy Board FAQ to the 'General' area of the 'COVID-19 Vaccines' section.

[21/05/2021 - 16:40]

Added links to the letter from the CMO and DCMO (Vaccines) on the change in advice related to provision of COVID-19 vaccines in light of JCVI advice to the 'Wales' area of the 'COVID-19 Vaccines' section.

[10/05/2021 - 10:49]

Added links to the letter from the CMO and DCMO (Vaccines) and the Welsh Government press release on the change in advice related to provision of the AstraZeneca vaccine to the 'Wales' area of the 'COVID-19 Vaccines' section.

[29/04/2021 - 12:23]

Added link to RCOG guidance on 'COVID-19 vaccines and pregnacy' to 'COVID-19 vaccines' page (within 'General' sub-section).

[19/04/2021 - 09:43]

New letter from the CMO and DCMO (Vaccines) added to the 'Wales' area of the 'COVID-19 Vaccines' section.

[14/04/2021 - 11:11]

New letter from the CPO for Wales, Therapeutic alert and Interim Position Statement on the use of budesonide for adults (50 years and over) with COVID-19 added to the 'COVID-19 Therapies - alerts and advice' page.

[31/03/2021 - 16:26]

Added 'Moderna COVID-19 vaccine: Directions and immunisation scheme specification for primary care' to the 'COVID-19 vaccines' page (within 'Wales' sub-section).

[26/03/2021 - 16:03]

Added 'National protocol for COVID-19 moderna vaccine' to the 'COVID-19 vaccines' page (within the 'Wales' sub-section).
Updated links in 'MHRA guidance on Coronavirus (COVID-19) - Vaccines and vaccine safety' within the 'COVID-19 vaccines' page (within the 'General' sub-section).

[23/03/2021 - 16:45]

Updated entry for 'NICE' (to include 'Managing COVID-19') within 'General information sources'.
Removed reference to SPS information on 'Management of drugs requiring monitoring during COVID-19' and 'Drug monitoring: Factors to consider' within the entry for 'DMARDs' in 'Specific areas of interest', due to the information no longer being available. 

[17/03/2021 - 14:12]

New alert from the CMO for Wales and Therapeutic Alert for 'Convalescent plasma' added to the 'COVID-19 Therapies - alerts and advice' page.

[08/03/2021 - 11:04]

Updated 'Vaccination Strategy for Wales' added to the 'COVID-19 vaccines' page (within the 'Wales' sub-section).

[19/02/2021 - 15:12]

New letter from the CMO for Wales, Therapeutic alert and Interim Clinical Commissioning Policies for Sarilumab and Tocilizumab (IL-6 inhibitors) added to the 'COVID-19 Therapies - alerts and advice' page.

[15/02/2021 - 09:36]

New letter from the CMO for Wales and Therapeutic alert for Colchicine added to the 'COVID-19 Therapies - alerts and advice' page.

[02/02/2021 - 16:05]

Renamed 'Vitamin D' section to 'Nutrition and inherited metabolic disorders' in 'Specific ares of interest' and added NHS SPS guidance on nutritional and inherited metabolic disorders. This SPS link has been added to 'General information sources' also.

NHS SPS information on COVID-19 vaccination in women of child-bearing age or who are pregnant has been added to the 'COVID-19 vaccines' page.

BTS information for the respiratory community added to the 'General information sources' page.

[01/02/2021 - 16:49]

New letter from the CMO for Wales, Therapeutic alert and Interim Commissioning Policies for Sarilumab and Tocilizumab (IL-6 inhibitors) added to the 'COVID-19 Therapies - alerts and advice' page.

[29/01/2021 - 16:42]

Letter from the CPO for Wales and the All Wales Specialist Pharmacist - Contingency Planning added on the 'COVID-19 Therapies - alerts and advice' page, addressing supply of baricitinib for patients recruited to the RECOVERY trial.

[29/01/2021 - 11:46]

New Therapeutic Alert and covering letter from the CMO for Wales added for microbials (azithromycin and doxycycline), on the 'COVID-19 Therapies - alerts and advice' page.

[27/01/2021 - 16:52]

Additional MHRA links regarding the Moderna vaccine added to the 'COVID-19 vaccines' page.

[22/01/2021 - 11:18]

Added NICE Rapid Evidence Summary for Sarilumab to 'COVID-19 therapies - alerts and advice' and 'COVID-19 General information sources' pages.

[20/01/2021 - 17:10]

Added NICE Rapid Evidence Summary for Tocilizumab added to 'COVID-19 therapies - alerts and advice' and 'COVID-10 General information sources' pages.

Added SPS resource on 'Reporting suspected COVID-19 vaccine side effects, and potential product defects or counterfeit products' to 'COVID-19 vaccines' and 'COVID-19 General information sources' pages.

[07/01/2021 - 14:45]

Additional links added to 'COVID-19 vaccines' page.

[31/12/2020 - 14:53]

Additional MHRA links regarding the Oxford University/AstraZeneca COVID-19 vaccines added to the 'COVID-19 vaccines' page.

[23/12/2020 - 16:18]

Added therapeutic alert for 'Anticoagulation (Heparin)' to the 'COVID-19 therapies - alerts and advice' page.

[23/12/2020 - 14:06]

Added a new 'Vitamin D' section to 'Specific areas of interest'.
Amended the NHS SPS section of 'General information sources' to replace outdated links and additional links.
Added two additional links to the NICE rapid guidelines listing in 'General information sources'.
Additional link to NHS SPS resources added to the 'COVID-19 vaccines' page.
Additional link to Welsh Government National Protocol for the Pfizer BioNTech COVID-19 vaccine added to the 'COVID-19 vaccines' page.

[11/12/2020 - 10:27]

Additional link to 'Confirmation of guidance to vaccination centres on managing allergic reactions following COVID-19 vaccination with the Pfizer/BioNTech vaccine' MHRA Press Release added to 'COVID-19 vaccines' page.

[08/12/2020 - 16:30]

A new 'COVID-19 vaccines' area has been added, providing links to useful resource related to the development and roll-out of COVID-19 vaccines.

[26/11/2020 - 09:39]

New Therapeutic Alert, Interim Position Statement and covering letter from the CPO for Wales added for tocilizumab, on the 'COVID-19 Therapies - alerts and advice' page.
Updated entry for 'NICE' (to include Reducing risk of venous thromboembolism in over 16s with COVID-19) within 'General information sources'.
Added entry for 'MHRA guidance on coronavirus' within 'General information sources'.

[09/11/2020 - 13:45]

New Therapeutic Alert, Interim Clinical Commissioning Policy and covering letter from the CPO for Wales added for remdesivir, on the 'COVID-19 Therapies - alerts and advice' page.

[27/10/2020 - 12:44]

Entries for 'Anticoagulants', 'DMARDs (including monoclonal antibodies)' and 'Immunosuppressants and corticosteroids' on the 'Specific areas of interest' page have been updated to reflect the most current guidance.

[20/10/2020 - 15:10]

New Rapid Policy Statement for palivizumab added to the 'COVID-19 Therapies - alerts and advice' page.

[15/10/2020 - 11:07]

Entry for 'Anticoagulants' on the 'Specific ares of interest' page has been updated to include MHRA advice.

[06/10/2020 - 13:39]

Entry for 'Anaesthesia and intensive care medicines' on the 'Specific areas of interest' page has been updated to highlight where some of the linked-to resources have now been archived.

[30/09/2020 - 15:56]

New Supply Disruption Alert for remdesivir added to the 'COVID-19 Therapies - alerts and advice' page.

[03/09/2020 - 12:47]

Updated entries on the 'COVID-19 Therapies - alerts and advice' page.
New alert for 'Corticosteroids' replaces previous alert specific to 'Dexamethasone'.
Updated alert for 'Remdesivir'.

[27/08/2020 - 15:06]

Added entry for 'Coronavirus (COVID-19) - Cochrane resources and news' on 'General information sources' page.

[07/07/2020 - 09:32]

Updated entries for 'Remdesivir' on the 'COVID-19 Therapies - alerts and advice' page, to link to latest Rapid Policy Statement and associated letter from the Chief Pharamceutical Officer for Wales.

[22/06/2020 - 15:31]

Updated entry for 'NICE' (to include Renal transplantation) within 'General information sources'.

[18/06/2020 - 14:31]

Content for 'Immunosuppressants' within 'Specific areas of interest' has been retitled to 'Immunosuppressants and corticosteroids' and update to incorporate more recent advice on the use of corticosteroids during the COVID-19 pandemic.

'COVID-19 Therapies' page renamed to 'COVID-19 Therapies - alerts and advice'.

Link to the COVID-19 Therapeutic alert for dexamethasone added to the 'COVID-19 Therapies - alerts and advice' page.

[12/06/2020 - 12:17]

Direct link to MHRA 'EAMS: Remdesivir treatment protocols' added to 'COVID-19 therapies' section.
Link to NICE Rapid Evidence Summary for remdesivir added to 'COVID-19 therapies' section.

[10/06/2020 - 12:17]

New 'Care home prescribing' section added.

[03/06/2020 - 12:17]

New 'COVID-19 therapies' section added.

[29/05/2020 - 16:51]

Updated link within 'Information for hospital pharmacists' to link to RPS Critical Care Training Resource. Previous link to 'Handbook - Introduction to Critical Care' was no longer active.

[19/05/2020 - 16:35]

The 'All Wales Medicines Access guidance' section has been updated and republished.

[18/05/2020 - 11:31]

Updated entry for 'NICE' (to include 'Chronic kidney disease' and 'Interstitial lung disease') within 'General information sources'.

[13/05/2020 - 14:57]

Added content on 'Valproate and pregnancy prevention programmes' within 'Specific areas of interest'.

Moved content on reporting of adverse events from 'General information sources' to a new section entitled 'Medicines safety' - this section also includes a link to the YCC Wales website.

[12/05/2020 - 11:18]

The 'All Wales Medicines Access Guidance' section has been removed temporarily - Update in progress.

[07/05/2020 - 15:23]

Expanded content on 'End of Life care' within 'Specific areas of interest' to include links to SOP for 'Running an END OF LIFE medicines reuse scheme in a care home or hospice setting'. Link to the same SOP also added to the 'Supplementary information on medicines supply' section.

[06/05/2020 - 17:10]

Added new section for 'All Wales Medicines Access policies'

[05/05/2020 - 15:16]

Expanded content on the 'ACMD advice on COVID-19 emergency legislation to enable to supply of controlled drugs' within 'Supplementary information on medicines supply', to include a recent statement from GPhC clarifying how these measures are not yet in effect but may potentially be introduced in certain circumstances.

[05/05/2020 - 11:03]

Link added under 'Yellow card reporting during the coronavirus outbreak' (within 'General information resources') to the MHRA's dedicated 'Coronavirus Yellow Card Reporting' website.

[04/05/2020 - 11:58]

Updated entry for 'NICE' (to include 'Children and young people who are immunocompromised') within 'General information sources'.

Added entry for 'All Wales COVID-19 Secondary Care Management Guideline' within 'Information for hospital pharmacists'.

[01/05/2020 - 14:57]

Content for 'Warfarin and INR testing' has been moved into 'Anticoagulant services' and expanded to include guidance on switching to DOACs and 'Vitamin B12 injections' content has been updated with new BSH guidance within 'Specific areas of interest'. Links have been updated for British Transplant Society and Association of British Neurologists advice in 'Immunosuppressants' within 'Specific areas of interest'.

[29/04/2020 - 12:43]

Content for 'Vitamin B12 injections' has been removed temporarily from 'Specific areas of interest', while the content is updated to reflect the latest BSH guidance.

[24/04/2020 - 13:12]

Updated entry for 'Warfarin and INR testing' (to include both SPS advice [primary care] and BSH advice [out-patients]) within 'Specific areas of interest'.

[24/04/2020 - 11:42]

Updated entry for 'NICE' (to include 'Gastrointestinal and liver conditions treated with drugs affecting the immune response' and 'Acute myocardial injury') within 'General information sources'.

[23/04/2020 - 14:48]

Updated entry for 'Anaesthesia and Intensive Care Medicines' within 'Specific areas of interest' to include additional direct links to guidance, and update existing links.

Added entry for RPS COVID-19 resources page within 'General information sources'.

[21/04/2020 - 15:09]

Added entry for 'Vitamin B12' within 'Specific areas of interest'.

[17/04/2020 - 16:45]

Added entry for 'Prostate cancer - One Wales Decision' within 'Specific areas of interest'.

[17/04/2020 - 12:14]

Titles for advice included within 'Specific areas of interest' have been amended and alphabetised to aid navigation.

[16/04/2020 - 13:56]

Updated the entry for 'NSAIDs' and 'End of Life care' within 'Specific areas of interest'.

[15/04/2020 - 14:43]

Updated entry for 'Patients on Warfarin' to link to SPS advice, and updated the reference link in the entry for 'No significant risk of infection associated with using nebulisers to administer medication' within 'Specific areas of interest'.

Updated the the entry for 'Specialist Pharmacy Service' to include direct link to 'Guidance on the management of drugs requiring monitoring during COVID-19' within 'General information sources'.

[14/04/2020 - 19:29]

Added section for 'End of Life COVID-19 Service'.

[14/04/2020 - 12:42]

Expanded entry for 'Advice on DMARDs (including monoclonal antibodies' to include additional information on Drug Monitoring and added a new entry for 'Management of immunosuppressants during the COVID-19' within 'Specific areas of interest'.

Added entry for 'ACMD advice on COVID-19 emergency legislation to enable supply of controlled drugs' within 'Supplementary information on medicine supply'.

[08/04/2020 - 11:25]

Expanded entry for 'NHS Specialist Pharmacy Service - Coronavirus COVID-19 resources' within 'General information sources' to signpost to specific useful resources and to their wider 'COVID-19 resources' landing page.

[07/04/2020 - 11:04]

Added 'End of life care' within 'Specific areas of interest'. Added 'COVID-19 Resource Hub (RCGP Learning)' and updated entry for 'NICE' (to include 'managing symptoms in the community', 'managing pneumonia in the community', 'rheumatological autoimmune, inflammatory and metabolic bone disorders', and 'severe asthma') within 'General information sources'.

[03/04/2020 - 16:14]

To alleviate access issues for many users, the link for 'Patient FAQ' within  'Anaesthesia and Intensive Care Medicines Guidance' has been replaced with a PDF version of the webpage.

[03/04/2020 - 11:20]

Added 'Anaesthesia and Intensive Care Medicines Guidance' within 'Specific areas of interest'. Added 'Yellow care reporting during the COVID-19 outbreak' within 'General information sources'. Added 'Examples of notable practice in pharmacy during the COVID-19 pandemic' within 'Information for community pharmacy'.

[02/04/2020 - 11:18]

Amended 'Advice on INR testing' within 'Specific areas of interest' to now link directly to the INR advice publication, and add a separate link to the BSH COVID-19 Updates webpage. Updated entry for 'NICE' (to include Haematopoietic stem cell transplantation) within 'General information sources'.

[01/04/2020 - 11.05]

Added 'Advice on INR testing' within 'Specific areas of interest'. Added 'Health Education England learning from home programme' within 'General information sources'.

[01/04/2020 - 09.15]

Updated format of entire resource hub - sections now divided into separate pages and navigation is now via a menu on the right hand side (bottom on mobile). Newest items are now listed at the top of each page.

[31/03/2020 - 11:10]

Updated 'Advice on the use of  ACEi and ARBs' to refer to MHRA guidance and added entry for 'Use of Rescue Packs' within 'Specific areas of interest'. Added section for 'Information for hospital pharmacists' and included reference to 'Critical care handbook'. Added links to 'Oxford CEBM' and 'HTW', and updated entry for 'NICE' (to include Radiotherapy) within 'General information sources'.

[28/03/2020 - 10:50]

Information on use of nebulisers, managing delirium, living with diabetes and DMARDs (including monoclonal antibodies) added within 'Specific areas of interest'. Information on ABPI added into 'General information sources'.

[27/03/2020 - 11:03]

Advice on 'use of chloroquine and hydroxychloroquine' and 'lithium' added to 'Specific areas of interest'. Entry for 'NICE Coronavirus rapid guidelines and evidence reviews' within 'general information sources' expanded to provide direct links to current rapid guidelines.

[26/03/2020 - 12:38]

Added 'unless advised by a healthcare professional' to point on use of NSAIDs for 'other medical reasons (e.g. arthritis)'

[26/03/2020 - 11:03]

'COVID-19 infection and monitoring of patients taking clozapine' added to 'Specific areas of interest'

[25/03/2020 - 15:40]

Brief summaries of 'Specific areas of interest' advice added.

Follow AWTTC: