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linagliptin/metformin (Jentadueto®)

 

Following a limited submission

AWMSG advice

Status: Recommended

Linagliptin / metformin (Jentadueto®) is recommended as an option for use within NHS Wales for the treatment of adult patients with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycaemic control:

  • in patients inadequately controlled on their maximally tolerated dose of metformin alone
  • in combination with other medicinal products for the treatment of diabetes, including insulin, in patients inadequately controlled with metformin and these medicinal products
  • in patients already being treated with the combination of linagliptin and metformin as separate tablets.
 Final Recommendation: linagliptin/metformin (Jentadueto) 2446 (PDF, 393Kb)
 Appraisal Report: linagliptin-metformin (Jentadueto) 2446 (PDF, 1.1Mb)

Medicine details

Medicine name linagliptin/metformin (Jentadueto®)
Formulation 2.5 mg/1000 mg film-coated tablet, 2.5 mg/850 mg film-coated tablet
Reference number 2446
Indication

Treatment of adult patients with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycaemic control: in patients inadequately controlled on their maximally tolerated dose of metformin alone; and in combination with other medicinal products for the treatment of diabetes, including insulin, in patients inadequately controlled with metformin and these medicinal products; and, in patients already being treated with the combination of linagliptin and metformin as separate tablets.

Company Boehringer Ingelheim Ltd
BNF chapter Endocrine system
Submission type Limited
Status Recommended
Advice number 2114
NMG meeting date 18/06/2014
AWMSG meeting date 16/07/2014
Ratification by Welsh Government 13/08/2014
Date of issue 14/08/2014
Date of last review 23/04/2019
Further information

This advice incorporates and replaces the existing AWMSG recommendation on linagliptin/metformin (Jentadueto® ) as an option for use within NHS Wales for the treatment of adult patients with type 2 diabetes mellitus:

  • as an adjunct to diet and exercise to improve glycaemic control in adult patients inadequately controlled on their maximal tolerated dose of metformin alone, or those already being treated with the combination of linagliptin and metformin; and
  • in combination with a sulphonylurea (i.e. triple combination therapy) as an adjunct to diet and exercise in adult patients inadequately controlled on their maximal tolerated dose of metformin and a sulphonylurea (Advice number 1113, originally published May 2013).
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