Medicine details

In combination with methotrexate or alone for the treatment of moderate to severe active rheumatoid arthritis in adults when the response to other disease-modifying anti-rheumatic drugs, including methotrexate (unless contraindicated), has been inadequate.Treatment of active and progressive psoriatic arthritis in adults when the response to previous disease modifying anti- rheumatic drug therapy has been inadequate. Treatment of adults with severe active ankylosing spondylitis who have had an inadequate response to conventional therapy.  Treatment of adults with severe non- radiographic axial spondyloarthritis with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI) evidence, who have had an inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs). Treatment of adults with moderate to severe plaque psoriasis who failed to respond to, or who have a contraindication to, or are intolerant to other systemic therapy, including ciclosporin, methotrexate or psoralen and ultraviolet-A light (PUVA)