Emtricitabine / tenofovir disoproxil is recommended for use within NHS Wales in combination with safer sex practices for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection in adults at high risk. Adults at high risk include the following populations:

• men who have sex with other men (MSM) and transgender people having sex with men who are engaging in condomless anal sex
• heterosexual and same-sex, HIV-1 negative partners who are in relationships with HIV-1 positive partners whose viral replication is not suppressed
• other heterosexuals considered to be at high risk

Emtricitabine / tenofovir disoproxil should be prescribed on the basis of lowest acquisition cost.