In the absence of a submission from the holder of the marketing authorisation, bendamustine (Levact®) cannot be endorsed for use within NHS Wales for the front line treatment of multiple myeloma (Durie-Salmon stage II with progress or stage III) in combination with prednisone for patients older than 65 years who are not eligible for autologous stem cell transplantation and who have clinical neuropathy at time of diagnosis precluding the use of thalidomide or bortezomib containing treatment.