Aripiprazole (Abilify®) is recommended as an option for use within NHS Wales for the treatment of moderate to severe manic episodes in Bipolar I Disorder and for the prevention of a new manic episode in patients who experienced predominantly manic episodes and whose manic episodes responded to aripiprazole treatment. Aripiprazole (Abilify®) may be suitable for shared care when used for long term treatment (i.e. prevention of manic episode) after hospital initiation.