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alogliptin / metformin (Vipdomet®)

 

Following a limited submission

AWMSG advice
Status: Recommended with restrictions

Alogliptin / metformin (Vipdomet®) is recommended as an option for restricted use for dual oral therapy within NHS Wales. Alogliptin / metformin (Vipdomet®) should be restricted for use in the following circumstances within its licensed indication for the treatment of adult patients aged 18 years and older with type 2 diabetes mellitus:

  • As an adjunct to diet and exercise to improve glycaemic control in adult patients, inadequately controlled on their maximal tolerated dose of metformin alone, or those already being treated with the combination of alogliptin and metformin as separate tablets.

Alogliptin / metformin (Vipdomet®) is not recommended for use within NHS Wales outside of these circumstances.
 Appraisal Report: alogliptin / metformin (Vipdomet) 1271 (PDF, 310Kb)

Medicine details
Medicine name alogliptin / metformin (Vipdomet®)
Formulation 12.5 mg / 1000 mg film-coated tablet
Reference number 1271
Indication

Treatment of adult patients aged 18 years and older with type 2 diabetes mellitus:

  • As an adjunct to diet and exercise to improve glycaemic control in adult patients, inadequately controlled on their maximal tolerated dose of metformin alone, or those already being treated with the combination of alogliptin and metformin;
  • In combination with pioglitazone (i.e. triple combination therapy) as an adjunct to diet and exercise in adult patients inadequately controlled on their maximal tolerated dose of metformin and pioglitazone;
  • In combination with insulin (i.e. triple combination therapy) as an adjunct to diet and exercise to improve glycaemic control in patients when insulin at a stable dose and metformin alone do not provide adequate glycaemic control
Company Takeda UK Ltd
BNF chapter Endocrine system
Assessment type Limited
Status Recommended with restrictions
Advice number 3314
NMG meeting date 10/09/2014
AWMSG meeting date 08/10/2014
Ratification by Welsh Government 30/10/2014
Date of issue 31/10/2014
Date of last review 13/12/2017
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